SCIENTIFICALLY PROVEN

Effective & Safe

YHK Therapy is a scientifically based therapy that is designed to improve liver health.
With a selection of powerful and effective ingredients, YHK is made by a patented formula.

Research shows that YHK contains properties which can improve ALT (GPT) liver enzyme level and prevent liver injury, significantly enhance liver health and liver function. This evidence-based natural compound is recommended for people who have chronic liver problems.


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SUPPORT LIVER HEALTH

YHK is a evidence based liver therapy. These data are
published in medical journals and some are listed on
the U.S. National Library of Medicine (PubMed.gov).

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3 UNIQUE PROPERTIES

Research studies show that YHK contains anti-fibrosis
properties which help the liver to prevent scar tissues
and reduce the risks of abnormal liver cells growth.

• Anti-Inflammatory
• Anti-Fibrotic
• Antioxidative

NATURAL PATENTED FORMULA

YHK is made by a patented formula with 4 highly respected and
well-studied herbs, including Panax Pseudo Ginseng,
Eucommia Ulmoides, Licorice Root and Rhizoma Polygonati.
These herbs are known to have strong healing effects in the
body and liver with antioxidants properties.

* Research shows that YHK does not have side effects.

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Testimonial


Gain an insight into YHK from our customers’ point of view.
What makes YHK such a unique and trusted therapy for liver patients?
You can find your answer right here.

* More user reviews on YHK's Facebook Page .





Research



1

Effect and Application of Yojyo Henshiko

S. Sha 1), N. Yanaihara 2)

Hepatitis C

Conferences:

16th General Meeting of Medical and Pharmaceutical Society for Wakan-Yaku
28th~29th August 1999 – Makuhari, Japan

2

Clinical Application and Efficacy of a New Chinese Medical Herb Prescription: “Yojyo Henshiko”

S. Sha 1), N. Yanaihara 2)

Hepatitis B
Hepatitis C

Conferences:

2nd Annual Meeting of the Japanese Society for Alternative Medicine & Treatment
10th~11th October 1999 – Yokohama, Japan

Clinical Study

3

Effect of “Yojyo Henshiko, a new Chinese Herb Prescription”, on Serum ALT and AST Levels in Patients with Hepatic Diseases

S. Sha 1), M.Harada 2), N. Yanaihara 3)

Hepatitis C

Conferences:

3rd International Conference on Therapies for Viral Hepatitis
12th~16th December 1999 – Maui, Hawai, U.S.A.

IASL-APASL JOINT MEETING 2000
2nd~7th June 2000 – Fukuoka, Japan

4

Beneficial Effect of a Controlled Chinese Herbal Remedy, K-17.22, in CCL4-Induced Liver Toxicity; an in Vivo and in Vitro Study

F.Marotta 1), A.Rouge 2), H.Anzulovic 2), M.Harada 3), G.M.Ideo 1), K.Kajikawa 4), N.Yanaihara 5), G.Princess 2), G.Ideo 1)

LIVER PROTECTION

Conferences:

4th JSH International Symposium on Liver Cirrhosis & Liver Cancer; 37th Annual Meeting of Liver Cancer Study Group of Japan
7th~9th June 2001 – Shimonoseki, Japan

European Association for the Study of the Liver
12th~13th October 2001 – Florence, Italy

5

Ischemia-Reperfusion Liver Injury: Effect of a Nutritional Approach with K-17.22 on Eudogenous Hepatic Antioxidant System

F.Marotta 1), G.M.Ideo 1), MG Seal 2), CC Wu 3), P Safran 2), M.Harada 4), N. Yanaihara 4), G.Ideo 1)

Hepatic ischemia

Conferences:

4th JSH International Symposium on Liver Cirrhosis & Liver Cancer; 37th Annual Meeting of Liver Cancer Study Group of Japan
6th~9th June 2001 – Shimonoseki, Japan

6

A Nutritional Approach with Herbal Remedy K-17.22 Delays the Onset of Spontaneous Chronic Pancreatitis

F.Marotta 1), M.Harada 2), MG Seal 2), J.Bertuccelli 3), A.Rouge 3), H.Anzulovic 3), N.Yanaihara 4), G.Ideo 1)

Chronic pancreatitis

Conferences:

25th National Congress of the Italian Association of Pancreatology Study
20th~22nd June 2001 – Como, Italy

7

Effect of a Nutritional Approach with K-17.22 on Endogenous Hepatic Antioxidant System

F.Marotta, M. Harada, N. Yanaihara, G.M. Ideo, MG Seal, CC Wu, P Safran, G.Ideo

Hepatitis C
Hepatic ischemia

Conferences:

European Association for the Study of the Liver
12th~13th October 2001 – Florence, Italy

8

The Effect of the Yojyo Hen Shi Ko for the liver diseases -Specially for the Hepatitis Type C

M.Harada, N.Yanaihara, F.Marotta, I.Yoshijima, H.Shimizu, K.Hosokawa, Y.Tsuji, Y.Harada, S.Sha

Hepatitis C

Conferences:

The 43th The Journal of All Japan Hospital Association
20th October 2001 – Saitama, Japan

9

The Effect of the Tablets

S. Sha 1), M. Harada 2), N. Yanaihara 3)

Hepatitis B
Hepatitis C
Cirrhosis
Fatty liver
Liver cancer

Conferences:

The 4th Annual Meeting of the Japanese Society for Alternative Medicine and Treatment
10th~11th November 2001 – Osaka, Japan

10

Effect of “Yojyo Henshiko (YHK)”, in Patients with Hepatic Diseases

S. Sha 1), M. Harada 2), N. Yanaihara 3)

Hepatitis B
Hepatitis C
Cirrhosis
Fatty liver
Liver cancer

Conferences:

HEP DART 2001
16th~20th December 2001 – Maui, Hawai, U.S.A.

Clinical Study

11

Effect of K-17.22, a Novel Phytoterapeutic Agent, on DNA Synthesis and Liver Enzyme Release in Experimental Liver Damage

F.Marotta 1), 2 YR-Shield 2), E.Minelli 3), A.Helmy 4), P.Safran 2), M.Harada 5)

Hepatitis C
Liver cancer

Conferences:

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

12

Is There Any Liver Anti-Fibrotic Effect of K-17.22? An Experimental Study with Immunohistochemical Analysis in A Rat Model

F.Marotta 1), 2 YR-Shield 2), E.Minelli 3), E. Oliva 4), P.Safran 2), M.Harada 5)

Liver fibrosis

Conferences:

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

14

Effect of a Novel Phytoterapeutic on DNA Synthesis and Enzyme Release In Experimental Liver Damage

F.Marotta 1), YR-Shield 2), E.Minelli 3), A Helmy 4), P.Safran 2)

Hepatitis C

Conferences:

First National Herb and Spice Conference: Grassroots to Global Enterprise
18th~19th February 2004 – Ontario, Canada

15

For “Shining of Life Force”-Basics & Potential Contribution of Yojyo Foods

S. Sha

Conferences:

First National Herb and Spice Conference: Grassroots to Global Enterprise
18th~19th February 2004 – Ontario, Canada

16

An In Vitro Study on the Beneficial Effect of YHK, A Natural Herbal Compound, on Metal-Induced Oxidative Damage of Hepatocytes and Mithocondrial Fraction

F.Marotta 1), P.LeCroix 2), M.Harada 3), K.Masulair 4), C.Turnes 2), P.Safran 3), E.Fesce 1)

Liver Health

Conferences:

7th International ISSX Meeting
29th August~2nd September 2004 – Vancouver, Canada

17

Herbal Products for Liver Disease: A Therapeutic Challenge for the New Millenium

F.Marotta

Hepatitis C
Hepatic ischemia
Liver cancer
Liver fibrosis

Conferences:

Hiroshima University M.D. Lecture Presentation
4th October 2004 – Hiroshima, Japan

18

Exploring Strategies to Treat NASH: Beneficial Effect of YHK on Metal-Induced Oxidative Damage of Hepatocytes and Lysosomal Fraction

F.Marotta, P.LeCroix, M.Harada, K.Masulair, C.Turnes, L.Mondazzi, P.Safran, E.Fesce

NASH

Conferences:

Third JSH Single Topic Conference
7th~8th October 2004 – Kochi, Japan

4th World Congress on Trauma, Sjock, Inflammation and Sepsis – Pathophysiology, Immune Consequences and Therapy
4th November 2004 – Munich, Germany

2nd Natural Health Product Conference
11th~13th February 2005 – Vancouver, Canada

Award Winning

19

Integrative Medicine in the III Millenium: Herbal Products for Liver Disease

F. Marotta, E. Minelli, U. Solimene, SH Sha.

Hepatitis C

Conferences:

Saudi Gastroenterology Association
10th November~2nd December 2004 – Saudi Arabia

20

Herbal Products for Liver Disease

Conferences:

Asian Pacific Association for the Study of the Liver(APASL) Conference 2004
11th December 2004~15th January 2005 – New Delhi, India

21

Liver Exposure to Xenobiotics: The Aging Factor and Potentials for Functional Foods

F. MAROTTA, P. LECROIX, M. HARADA, K. MASULAIR, P. SAFRAN, A. LORENZETTI, SK ONO-NITA, and P. MARANDOLA

Liver Protection
Anti Ageing

Publication:

  • REJUVENATION RESEARCH Volume 9, Number 2, 2006

22

Yo Jyo Hen Shi Ko (YHK) Improves Transaminases in Nonalcoholic Steatohepatitis(NASH): A Randomized Pilot Study

Nilesh Chande, Maggie Laidlaw, Paul Adams, Paul Marotta

NASH

Conferences:

1st Annual Canadian Association for the Study of the Liver
Winter Meeting: Updates in Hepatology
19th~22nd March 2005 – Canada

Publication:

  • Digestive Diseases and Sciences 2006

Clinical Study

23

Carcinogen-Metabolizing Enzyme Activity in the Liver: Beneficial Effect of the Phytotherapeutic Compound YHK

F. Marotta 1), P. LeCroix 2), M. Harada 3), K. Masulair 4), P. Safran 3), E. Fesce 1)

Liver cancer

Conferences:

8th World Congress on Gastrointestinal Cancer
28th June~1st July 2006 – Barcelona, Spain

24

Nonalcoholic Steatohepatitis (NASH) in OB/OB Mice Treated with Yo Jyo Hen Shi Ko (YHK): Effects on Peroxisome Proliferator-Activated Receptors (PPARs) and Microsomal Triglyceride Transfer Protein (MTP)

J. T. Stefano, C. P. M. S. de Oliveira, M. L. Correˆa-Giannella, V. M. R. de Lima, S. V. de Sa, E. P. de Oliveira, E. S. de Mello, D. Giannella-Neto, V. A. F. Alves, F. J. Carrilho

NASH

Publication:

  • Digestive Diseases and Sciences Vol.52, 2007

25

YHK(YojyoHenshiKo), a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine-choline-deficient diet

Lima V.M.1, Oliveira C.P 1), Sawada L.Y 1), Barbeiro H.V 2), Mello E.S 3), Soriano F.G 2), Alves V.A.F 3), Caldwell S.H 4), Carrilho F.J 1)

NASH

Publication:

“Liver International” Volume 27, Issue2

26

In vitro study on the mechanisms of action of a novel phytotherapeutic compound against human hepatoma cells

F Marotta;1,3 M Harada;2 KL Goh;3 A Lorenzetti;4 P Marandola;4 E Minelli 1

Liver cancer

Publication:

Annals of Hepatology
1st April 2007

27

Phytotherapeutic compound YHK exerts an inhibitory effect on early stage of experimentally-induced neoplastic liver lesions

Marotta F;1,4 Harada M;2 Goh KL;3 Lorenzetti A;1 Gelosa F;1 Minelli E4

Liver cancer

Conferences:

International Symposium on: Functional Foods in Europe – International Developments in Science and Health Claims
9th~11th May 2007 – St Julian’s, Malta

American Institute for Cancer Research (AICR) Annual Conference on Food, Nutrition, Physical Activity and Cancer
6th~7th November 2008 – Washington DC, U.S.A.

Publication:

  • Annals of Hepatology 2006

30

Yo Jyo Hen Shi Ko (YHK) Modulates the Expression of Proteins Involved in de novo Lipogenesis and Lipid Exportation in Experimental Nonalcoholic Steatohepatitis (NASH)

I. Pereira, C. de Oliveira, J. Stefano, V. Debas, N. Halla, J. Alves, F. Laurindo, F. Carrilho

Liver cancer

Publication:

  • Journal of Pharmacy and Nutrition Science 2013

31

Biological evaluations of DTS and YHK on neuronal differentiation in PC12 cell model

Center for Chinese Medicine R&D – The Hong Kong University of Science and Technology

Neuron

Dosage Suggestion


YHK Therapy can help you to improve liver health and recover liver function.
It can also be used as a liver health supplement.

As each person’s liver condition and health needs are different,
you should find out which dosage is suitable for yourself.

Follow our guidelines below, and feel free to adjust the dosage according to your own needs.




3

Tablets

dosage-2 Users can take 3 tablets per day for liver support. We recommend this dosage for users who have normal liver function to prevent liver diseases, protection and maintain normal liver function.
Customers can take 6 tablets per day for enhance liver health and liver function. Suitable for people with abnormal liver function and patients with chronic liver problems. dosage-4

6

Tablets

6+

Tablets

dosage-5 Users are recommended to take a liver function test before and after using YHK. It is possible that some might require more tablets to support the liver. User should adjust dosage according to their test results and health level.


Storage Methods
• Keep in a dry, cool place. Avoid direct sunlight.
• Please take them at your earliest convenience after opening.
• You will also be able to see the storage information on the back of our packaging.
• All of our products are packed in a zipper bag. Zip up the bag after use to help maintain the condition of the tablets.