SCIENTIFICALLY PROVEN

Protection & Regeneration

Take care of your liver for a healthier life.

Made in Japan using a patented extraction method, YHK contains unique ‘3A’ properties (Anti-inflammation, Anti-fibrosis, and Antioxidant) that are proven to promote liver health.

Suitable for people who:
• Have poor liver function • Have excessive liver fat content
• Live a busy life • Are on long-term medication


yhk-f1

FLEXIBLE DOSAGE

YHK can be used as a liver protection on a low dosage
(1 tablet/ day) or as an option for liver recovery from
chronic liver problems on a higher dosage (6 tablets/ day).

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PROVEN LIVER PROTECTION

With a number of research studies, the postive effects
of YHK have been proven by users for over 25 years.
Take YHK on a lower dosage (1 tablets/ day), and it can
offer the liver with the perfect protection that is totally
unique and highly effective.

* For YHK’s published data on U.S. National Library of Medicine.

PATENTED EXTRACTION FORMULA

YHK is made using a patented formula with 4 highly respected and
well-studied herbs, including:
• Panax Pseudo Ginseng,
• Eucommia,
• Licorice Root, and
• Rhizoma Polygonati.

Patent Number:
• U.S.: 6586017
• Japan: 4588132
• Canada: 2291974
• Europe: 1002540
• China: ZL03107003.5

* VERIFIED:
The formula of YHK is tested in research and clinical applications.
Research data and users reports show that the formula of YHK
does not cause any side effects.

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PROFESSIONAL COMMENT ON YHK

“YHK has been shown to have antioxidant, hypoglycemic, antifibrotic and
lipid-lowering properties… to prevent NASH, promote weight loss, lower
serum aminotransferases, and reduce visceral fat… YHK has been
demonstrated to be safe with a significant reduction in alanine
aminotransferase (p = 0.036) in a small study of eight patients (five treatment)
with NASH…After discontinuation of the medication, there was an increase
of alanine aminotransferase towards baseline after 4 weeks.”

PMID: 21180532

Testimonial


Gain an insight into YHK from our customers’ point of view.
What makes YHK such a unique and trusted therapy for liver protection?
You can find your answer right here.

* More user reviews on YHK's Facebook Page .





Research



1

Effect and Application of Yojyo Henshiko

S. Sha 1), N. Yanaihara 2)

Hepatitis C

Conferences:

16th General Meeting of Medical and Pharmaceutical Society for Wakan-Yaku
28th~29th August 1999 – Makuhari, Japan

2

Clinical Application and Efficacy of a New Chinese Medical Herb Prescription: “Yojyo Henshiko”

S. Sha 1), N. Yanaihara 2)

Hepatitis B
Hepatitis C

Conferences:

2nd Annual Meeting of the Japanese Society for Alternative Medicine & Treatment
10th~11th October 1999 – Yokohama, Japan

Clinical Study

3

Effect of “Yojyo Henshiko, a new Chinese Herb Prescription”, on Serum ALT and AST Levels in Patients with Hepatic Diseases

S. Sha 1), M.Harada 2), N. Yanaihara 3)

Hepatitis C

Conferences:

3rd International Conference on Therapies for Viral Hepatitis
12th~16th December 1999 – Maui, Hawai, U.S.A.

IASL-APASL JOINT MEETING 2000
2nd~7th June 2000 – Fukuoka, Japan

4

Beneficial Effect of a Controlled Chinese Herbal Remedy, K-17.22, in CCL4-Induced Liver Toxicity; an in Vivo and in Vitro Study

F.Marotta 1), A.Rouge 2), H.Anzulovic 2), M.Harada 3), G.M.Ideo 1), K.Kajikawa 4), N.Yanaihara 5), G.Princess 2), G.Ideo 1)

LIVER PROTECTION

Conferences:

4th JSH International Symposium on Liver Cirrhosis & Liver Cancer; 37th Annual Meeting of Liver Cancer Study Group of Japan
7th~9th June 2001 – Shimonoseki, Japan

European Association for the Study of the Liver
12th~13th October 2001 – Florence, Italy

5

Ischemia-Reperfusion Liver Injury: Effect of a Nutritional Approach with K-17.22 on Eudogenous Hepatic Antioxidant System

F.Marotta 1), G.M.Ideo 1), MG Seal 2), CC Wu 3), P Safran 2), M.Harada 4), N. Yanaihara 4), G.Ideo 1)

Hepatic ischemia

Conferences:

4th JSH International Symposium on Liver Cirrhosis & Liver Cancer; 37th Annual Meeting of Liver Cancer Study Group of Japan
6th~9th June 2001 – Shimonoseki, Japan

6

A Nutritional Approach with Herbal Remedy K-17.22 Delays the Onset of Spontaneous Chronic Pancreatitis

F.Marotta 1), M.Harada 2), MG Seal 2), J.Bertuccelli 3), A.Rouge 3), H.Anzulovic 3), N.Yanaihara 4), G.Ideo 1)

Chronic pancreatitis

Conferences:

25th National Congress of the Italian Association of Pancreatology Study
20th~22nd June 2001 – Como, Italy

7

Effect of a Nutritional Approach with K-17.22 on Endogenous Hepatic Antioxidant System

F.Marotta, M. Harada, N. Yanaihara, G.M. Ideo, MG Seal, CC Wu, P Safran, G.Ideo

Hepatitis C
Hepatic ischemia

Conferences:

European Association for the Study of the Liver
12th~13th October 2001 – Florence, Italy

8

The Effect of the Yojyo Hen Shi Ko for the liver diseases -Specially for the Hepatitis Type C

M.Harada, N.Yanaihara, F.Marotta, I.Yoshijima, H.Shimizu, K.Hosokawa, Y.Tsuji, Y.Harada, S.Sha

Hepatitis C

Conferences:

The 43th The Journal of All Japan Hospital Association
20th October 2001 – Saitama, Japan

9

The Effect of the Tablets

S. Sha 1), M. Harada 2), N. Yanaihara 3)

Hepatitis B
Hepatitis C
Cirrhosis
Fatty liver
Liver cancer

Conferences:

The 4th Annual Meeting of the Japanese Society for Alternative Medicine and Treatment
10th~11th November 2001 – Osaka, Japan

10

Effect of “Yojyo Henshiko (YHK)”, in Patients with Hepatic Diseases

S. Sha 1), M. Harada 2), N. Yanaihara 3)

Hepatitis B
Hepatitis C
Cirrhosis
Fatty liver
Liver cancer

Conferences:

HEP DART 2001
16th~20th December 2001 – Maui, Hawai, U.S.A.

Clinical Study

11

Effect of K-17.22, a Novel Phytoterapeutic Agent, on DNA Synthesis and Liver Enzyme Release in Experimental Liver Damage

F.Marotta 1), 2 YR-Shield 2), E.Minelli 3), A.Helmy 4), P.Safran 2), M.Harada 5)

Hepatitis C
Liver cancer

Conferences:

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

12

Is There Any Liver Anti-Fibrotic Effect of K-17.22? An Experimental Study with Immunohistochemical Analysis in A Rat Model

F.Marotta 1), 2 YR-Shield 2), E.Minelli 3), E. Oliva 4), P.Safran 2), M.Harada 5)

Liver fibrosis

Conferences:

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

14

Effect of a Novel Phytoterapeutic on DNA Synthesis and Enzyme Release In Experimental Liver Damage

F.Marotta 1), YR-Shield 2), E.Minelli 3), A Helmy 4), P.Safran 2)

Hepatitis C

Conferences:

First National Herb and Spice Conference: Grassroots to Global Enterprise
18th~19th February 2004 – Ontario, Canada

15

For “Shining of Life Force”-Basics & Potential Contribution of Yojyo Foods

S. Sha

Conferences:

First National Herb and Spice Conference: Grassroots to Global Enterprise
18th~19th February 2004 – Ontario, Canada

16

An In Vitro Study on the Beneficial Effect of YHK, A Natural Herbal Compound, on Metal-Induced Oxidative Damage of Hepatocytes and Mithocondrial Fraction

F.Marotta 1), P.LeCroix 2), M.Harada 3), K.Masulair 4), C.Turnes 2), P.Safran 3), E.Fesce 1)

Liver Health

Conferences:

7th International ISSX Meeting
29th August~2nd September 2004 – Vancouver, Canada

17

Herbal Products for Liver Disease: A Therapeutic Challenge for the New Millenium

F.Marotta

Hepatitis C
Hepatic ischemia
Liver cancer
Liver fibrosis

Conferences:

Hiroshima University M.D. Lecture Presentation
4th October 2004 – Hiroshima, Japan

18

Exploring Strategies to Treat NASH: Beneficial Effect of YHK on Metal-Induced Oxidative Damage of Hepatocytes and Lysosomal Fraction

F.Marotta, P.LeCroix, M.Harada, K.Masulair, C.Turnes, L.Mondazzi, P.Safran, E.Fesce

NASH

Conferences:

Third JSH Single Topic Conference
7th~8th October 2004 – Kochi, Japan

4th World Congress on Trauma, Sjock, Inflammation and Sepsis – Pathophysiology, Immune Consequences and Therapy
4th November 2004 – Munich, Germany

2nd Natural Health Product Conference
11th~13th February 2005 – Vancouver, Canada

Award Winning

19

Integrative Medicine in the III Millenium: Herbal Products for Liver Disease

F. Marotta, E. Minelli, U. Solimene, SH Sha.

Hepatitis C

Conferences:

Saudi Gastroenterology Association
10th November~2nd December 2004 – Saudi Arabia

20

Herbal Products for Liver Disease

Conferences:

Asian Pacific Association for the Study of the Liver(APASL) Conference 2004
11th December 2004~15th January 2005 – New Delhi, India

21

Liver Exposure to Xenobiotics: The Aging Factor and Potentials for Functional Foods

F. MAROTTA, P. LECROIX, M. HARADA, K. MASULAIR, P. SAFRAN, A. LORENZETTI, SK ONO-NITA, and P. MARANDOLA

Liver Protection
Anti Ageing

Publication:

  • REJUVENATION RESEARCH Volume 9, Number 2, 2006

22

Yo Jyo Hen Shi Ko (YHK) Improves Transaminases in Nonalcoholic Steatohepatitis(NASH): A Randomized Pilot Study

Nilesh Chande, Maggie Laidlaw, Paul Adams, Paul Marotta

NASH

Conferences:

1st Annual Canadian Association for the Study of the Liver
Winter Meeting: Updates in Hepatology
19th~22nd March 2005 – Canada

Publication:

  • Digestive Diseases and Sciences 2006

Clinical Study

23

Carcinogen-Metabolizing Enzyme Activity in the Liver: Beneficial Effect of the Phytotherapeutic Compound YHK

F. Marotta 1), P. LeCroix 2), M. Harada 3), K. Masulair 4), P. Safran 3), E. Fesce 1)

Liver cancer

Conferences:

8th World Congress on Gastrointestinal Cancer
28th June~1st July 2006 – Barcelona, Spain

24

Nonalcoholic Steatohepatitis (NASH) in OB/OB Mice Treated with Yo Jyo Hen Shi Ko (YHK): Effects on Peroxisome Proliferator-Activated Receptors (PPARs) and Microsomal Triglyceride Transfer Protein (MTP)

J. T. Stefano, C. P. M. S. de Oliveira, M. L. Correˆa-Giannella, V. M. R. de Lima, S. V. de Sa, E. P. de Oliveira, E. S. de Mello, D. Giannella-Neto, V. A. F. Alves, F. J. Carrilho

NASH

Publication:

  • Digestive Diseases and Sciences Vol.52, 2007

25

YHK(YojyoHenshiKo), a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine-choline-deficient diet

Lima V.M.1, Oliveira C.P 1), Sawada L.Y 1), Barbeiro H.V 2), Mello E.S 3), Soriano F.G 2), Alves V.A.F 3), Caldwell S.H 4), Carrilho F.J 1)

NASH

Publication:

“Liver International” Volume 27, Issue2

26

In vitro study on the mechanisms of action of a novel phytotherapeutic compound against human hepatoma cells

F Marotta;1,3 M Harada;2 KL Goh;3 A Lorenzetti;4 P Marandola;4 E Minelli 1

Liver cancer

Publication:

Annals of Hepatology
1st April 2007

27

Phytotherapeutic compound YHK exerts an inhibitory effect on early stage of experimentally-induced neoplastic liver lesions

Marotta F;1,4 Harada M;2 Goh KL;3 Lorenzetti A;1 Gelosa F;1 Minelli E4

Liver cancer

Conferences:

International Symposium on: Functional Foods in Europe – International Developments in Science and Health Claims
9th~11th May 2007 – St Julian’s, Malta

American Institute for Cancer Research (AICR) Annual Conference on Food, Nutrition, Physical Activity and Cancer
6th~7th November 2008 – Washington DC, U.S.A.

Publication:

  • Annals of Hepatology 2006

30

Yo Jyo Hen Shi Ko (YHK) Modulates the Expression of Proteins Involved in de novo Lipogenesis and Lipid Exportation in Experimental Nonalcoholic Steatohepatitis (NASH)

I. Pereira, C. de Oliveira, J. Stefano, V. Debas, N. Halla, J. Alves, F. Laurindo, F. Carrilho

Liver cancer

Publication:

  • Journal of Pharmacy and Nutrition Science 2013

31

Biological evaluations of DTS and YHK on neuronal differentiation in PC12 cell model

Center for Chinese Medicine R&D – The Hong Kong University of Science and Technology

Neuron

Dosage Suggestion


YHK can be used on a low dosage for liver protection or on a high dosage
for recovery from chronic liver problems. As each person’s liver condition
and health needs are different, the user can adjust the dosage accordingly.




1

Tablet

dosage-2 For liver protection, take 1 tablet per day. This dosage is recommended for users who have good liver function and want to prevent liver injury. At US$2.5 per day, you can keep your liver healthy and stay away from liver problems!
Users can take 3 tablets/ day for better liver support. We recommend this dosage for users who previously have abnormal liver injury, and looking to maintain normal liver function to prevent future liver damage. dosage-4

3

Tablets

6

Tablets

dosage-5 Customers can take 6 tablets per day to enhance liver health and liver function. This dosage is suitable for people with abnormal liver function and patients with chronic liver problems.

Users are recommended to take a liver function test before and after using YHK.


How to Use & Storage
• For liver protection, take once per day with water at any time that is convenient for you.
• For people with poor liver health, take twice per day with water – once in the morning and once in the evening.
• YHK can be taken before or after meal.
• Keep in a dry, cool place. Avoid direct sunlight.
• Please take them at your earliest convenience after opening.